Effect of the concept of bronchopulmonary dysplasia into the neurodevelopmental effects

Effect of the concept of bronchopulmonary dysplasia into the neurodevelopmental effects

Understanding the short and long-term pulmonary and neurologic outcomes of neonates with bronchopulmonary dysplasia (BPD) is important in neonatal care for low-birth-weight infants. Different criteria for BPD may have different associations with long-term outcomes. Currently, two criteria for diagnosing BPD have been proposed by the NIH (2001) and NRN (2019) for preterm infants at a postmenstrual age (PMA) of 36 weeks. We investigated which BPD definition best predicts long-term outcomes. Korean nationwide data for preterm infants born between 24 +0 and < 32 +0 weeks gestation from were collected. For long-term outcomes, severity based on the NRN criteria was significantly related to neurodevelopmental impairment (NDI) in a univariate analysis after other risk factors were controlled. For the admission rate for respiratory disorder, grade 3 BPD of the NRN criteria had the highest specificity (96%), negative predictive value (86%), and accuracy (83%). For predicting NDI at the 18–24 month follow-up, grade 3 BPD of the NRN criteria had the best specificity (98%), positive (64%) and negative (79%) predictive values, and accuracy (78%) while NIH severe BPD had the highest sensitivity (60%). The NRN definition was more strongly associated with poor 2-year developmental outcomes. BPD diagnosed by NRN definitions might better identify infants at high risk for NDI.


Bronchopulmonary dysplasia (BPD) is a primary side-effect in the really low beginning weight infants (VLBWIs). Much more serious BPD was from the an elevated likelihood of developmental disability and you can smaller pulmonary means step one,2,step 3 . The span of the condition, for instance the requirement for rehospitalization and you will neurodevelopmental disability, is actually a noted concern certainly mothers and you can healthcare company 4 . Understanding how state seriousness is of this developmental decelerate and readmissions might help guide future look and you may top quality improvement attempts to reduce the duty for the disease.

BPD was first discussed from the Northway ainsi que al. 5 over 50 years ago; yet not, during the 2001, the new National Institute of Child Fitness (NIH) modified the brand new categorical significance out of BPD. Recently, inter-heart variability within the fresh air government and nasal cannula flow, along with the entry to noninvasive ventilation, can prejudice the brand new NIH group out of BPD visibility and seriousness. This means that, this type of widely used criteria may possibly not be appropriate for the present day scientific disease and/or anticipate out of much time-name outcomes of modern VLBWIs 6,seven . In accordance with this difference, Jensen mais aussi al. 8 recommended a special concept of BPD that top predicted very early childhood morbidity and categorized problem severity according to the mode regarding respiratory help, regardless of the use of extra fresh air. So it definition try modified in order to alot more accurately assume breathing readmission and you can developmental waits from inside the a good You.S.-born populace.

Hence, we lined up to determine which concept of BPD at the an excellent PMA of thirty-six months is actually most appropriate getting forecasting long-identity neonatal effects, eg pulmonary and you can neurological effects, counted at the 18–couple of years fixed years (CA), in good multicenter cohort study of VLBWIs in accordance with the across the country Korean Neonatal Circle (KNN) registry.


A maximum of 8294 children created between twenty-four +0 days and you may 30 +six weeks GA have been registered on KNN, Immediately following leaving out infants, 2889 VLBWIs remained; included in this, 1849 (64.0%) got done pursue-upwards pointers offered at Ca 18–couple of years, in addition to respiratory readmission and you may developmental effects (Fig. 1). Ones 1849 VLBWIs, 1221 (66.0%) got BPD with regards to the NIH meaning, together with 665 kids (36%) having light BPD, 184 children (10%) that have average BPD, and you can 372 infants https://datingranking.net/angelreturn-review/ (19%) having really serious BPD. Having said that 555 kids (30%) had BPD depending on the NRN meaning, plus 186 infants (10%) having values step one BPD, 303 kids (16%) with amount 2 BPD, and you will 66 infants (4%) that have stages step 3 BPD (Desk step one).